Let’s be honest: Pharmacology is often the “boogeyman” of the medical and nursing curriculum. It’s the one subject that requires you to be a part-time chemist, a part-time biologist, and a full-time mathematician. One minute you’re learning about how a molecule binds to a receptor, and the next, you’re calculating the steady-state concentration of a drug with a narrow therapeutic window.
Below is the exam paper download link
Past Paper On General Parmacology For Revision
Above is the exam paper download link
If your brain feels like a browser with fifty tabs open, you aren’t alone. But here’s a reality check: you don’t need to know every single drug in the Pharmacopeia to pass. You need to understand the principles. That is why we’ve curated a massive vault of General Pharmacology Past Papers for you to download.
By practicing with real questions, you’ll start to see the patterns that examiners love. To get you started, we’ve broken down four essential Q&As that appear in almost every revision cycle.
The Pharmacology Revision Q&A: Master the Fundamentals
1. What is the “First-Pass Effect,” and how does it change your prescription?
This is a classic “Short Answer” favorite. When you give a drug orally, it doesn’t go straight to the heart. It travels through the portal vein to the liver—the body’s ultimate filter. The liver often metabolizes a huge chunk of the drug before it ever reaches the rest of the body.
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The Exam Hack: If a question asks why a patient needs 100mg of a drug orally but only 5mg intravenously, the answer is almost always High First-Pass Metabolism.
2. How do Agonists, Antagonists, and Inverse Agonists actually differ?
Think of a receptor like a light switch:
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Agonist: Turns the light on (activates the receptor).
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Antagonist: Stands in front of the switch so nobody can touch it (blocks the receptor but has no effect of its own).
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Inverse Agonist: Turns the light off—even if there was a “dimmer” setting already running (reduces the basal activity of a receptor).
3. What is the difference between Zero-Order and First-Order Kinetics?
This is where the math usually trips people up.
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First-Order: A constant percentage of the drug is eliminated over time (most drugs do this).
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Zero-Order: A constant amount of the drug is eliminated regardless of how much is in the system (think Alcohol or Aspirin at high doses).
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The Catch: In Zero-Order, the body’s enzymes are saturated. If you take more, the levels in your blood skyrocket dangerously fast.
4. Why is the “Volume of Distribution” ($V_d$) a fake number?
The $V_d$ is a theoretical volume. It tells you if a drug likes to stay in the blood (Low $V_d$) or hide in the body’s fat and tissues (High $V_d$). If a drug has a $V_d$ of 500 Liters, obviously it isn’t all in your blood (you’d be a giant!). It just means the drug is heavily sequestered in tissues.
Why Downloading Past Papers is the Ultimate Shortcut
You can read Rang & Dale cover to cover, but until you sit down with a blank timer and a set of exam questions, you won’t know if the information is “sticky.” Using our past paper bundle allows you to:
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Identify the “High-Yield” Topics: You’ll notice that G-protein coupled receptors and Cytochrome P450 enzymes come up constantly.
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Practice the Calculations: Don’t let a Loading Dose calculation be the reason you lose ten marks.
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Build Exam Stamina: Pharmacology exams are dense. Practicing helps you learn when to move on from a tough question.
Get Your Study Materials Now
Don’t leave your grades to the mercy of a lucky guess. Our downloadable PDF pack contains the last five years of General Pharmacology papers, complete with marking schemes and expert rationales.
